• Hello, I'm Yutaka Hitomi.

    A designer of functional molecules

  • WHO I AM

    YUTAKA HITOMI

    Professor

    Department of Chemistry and Biochemistry

    Doshisha University

    1-3 Tatara Miyakodani, Kyotanabe

    Kyoto 610-0394, JAPAN

    yhitomi@mail.doshisha.ac.jp

     

    1990.4~1994.3

    Undergraduate Student

    Department of Synthetic Chemistry, Kyoto University

    Supervised by Prof. Yoshihiko Ito

    1994.4~1996.3

    Graduate Student (Master Course)

    Department of Synthetic Chemistry and Biological Chemistry,

    Graduate School of Engineering, Kyoto University

    Supervised by Prof. Hisanobu Ogoshi and Prof. Takashi Hayashi

    1996.4~1999.3

    Graduate Student (Doctor Course)

    Department of Synthetic Chemistry and Biological Chemistry,

    Graduate School of Engineering, Kyoto University

    Supervised by Prof. H. Ogoshi, Prof. Takashi Hayashi and Prof. Susumu Kitagawa

     

    1996.4~1999.3

    JSPS Research Fellow (DC1)

    1999.4~2000.9

    JSPS Research Fellow (PD)

    1999.4~2001.4

    Post-doctoral Fellow (Northwestern University, USA: Prof. Thomas V. O'Halloran)

     

    2001.5~2007.2

    Assistant Professor

    Department of Molecular Engineering, Graduate School of Engineering,

    Kyoto University (Prof. Takuzo Funabiki)
     

    2007.3~2008.3

    Lecturer in Chemistry

    Department of Molecular Engineering, Graduate School of Engineering,

    Kyoto University (Prof. Tsunehiro Tanaka)
     

    2008.4~2014.3

    Associate Professor

    Department of Chemistry and Biochemistry,

    Doshisha University (Prof. Masahito Kodera)
     

    2014.4~present

    Professor

    Department of Chemistry and Biochemistry,

    Doshisha University
     

    2017.10~present

    JST-PRESTO Researcher

    Japan Science and Technology Agency

  • RESEARCH INTERESTS

    Oxidation Catalysts: C-H Bond Activation, Selective Oxidation Catalysts

    Molecular Probes and Chemical Tools for Biological Studies: Fluorescent Probes for Hydrogen Peroxide, Ethylene Sensors, Photosensitive NO-Releasing Molecules, Peroxidase Mimetics, Mn-based MRI Contrast Agents

    Metal-based Antitumor Agents: Mn-Based SOD Mimetics, Fe-Based SOD Mimetics

    Bioinspired Catalyst for Selective Alkane Hydroxylation with Hydrogen Peroxide

    collaborator: Kengo Arakawa

    New Entry of Selective Oxidation Catalysts

     

    Selective oxidation: The success of the title reaction (see scheme) is caused by the strong electron donation from the amidate moiety of the dpaq ligand to the iron center (dpaq=2-[bis(pyridin-2-ylmethyl)]amino-N-quinolin-8-yl-acetamidate). This process facilitates the O-O bond heterolysis of the intermediate FeIIIOOH species to generate a selective oxidant without forming highly reactive hydroxyl radicals.

     

    Metal-Complex-Based Fluorescent Probes for Hydrogen Peroxide

    collaborator: Toshiyuki Takeyasu

    Rapid Detection of Hydrogen Peroxide in Water

     

    We developed a metal-based fluorescent probe for H2O2 called MBFh1, which has an iron complex as a reaction site for H2O2 and a 3,7-dihydroxyphenoxazine derivative as the fluorescent reporter unit. The iron complex reacts quickly with H2O2 to form oxidants, and then the oxidants convert the closely appended nonfluorescent 3,7-dihydroxyphenoxazine moiety to resorufin in an intramolecular fashion. The quick response to H2O2 allows us to plot the enzymatic evolution of H2O2.

     

    Bioinspired Ethylene Probe

    collaborator: Toshiyuki Nagai

    Reversible Formation of Silver-Ethylene Complex

     

    We have synthesised a silver(I) complex with a metal–arene interaction, where the anthracene ring of the ligand sidearm is positioned above the silver(I) ion. The interaction is disrupted by ethylene coordination to the silver(I). The reversible interconversion between the metal–arene and metal–ethylene interactions allowed us to monitor the presence of ethylene.

     

    Photoactive Nitric Oxide Donor

    collaborator: Yuji Iwamoto

    Photoresponsive Release of Nitric Oxide under Physiological Conditions

     

    We have prepared a series of manganese nitrosyl {MnNO}6 complexes. The nitro-substituted derivative is unique among the series; the tail of its absorption bands extends to the NIR region (up to 700 nm), and the apparent NO releasing rate from 1NO2 by light irradiation at 650 nm was ca. 4-fold higher than the other derivatives.

     

    Mn-based MRI contrast agent

    collaborators: Ryosuke Miyachi, Kazuki Aoki,Tomoyuki Ekawa

    Gold Nanoparticles Coated with Manganese-Porphyrin that Effectively Shorten the Longitudinal Relaxation Time of Water Molecules

     

    We have prepared gold nanoparticles coated with a monolayer of manganese(III) porphyrin complexes. The longitudinal relaxivity per Mn clearly increased as the particle size increased due to the rigid anchoring of manganese(III) porphyrin via four Au−S bonds.

     

    Uncaging an Intracellular Hydrogen Peroxide Generator 

    collaborator: Yuji Iwamoto

    Photoactivatable Metal Complex that Controls Cellular Functions

     

    The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}6 complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2

     

  • Working in Our Group

    We continually seek exceptional young researchers who are interested in the field of bioinorganic chemistry and/or oxidative stress. We welcome students from across the globe, to join us as graduate students and post-doctoral fellows.

     

    Master course studentships

    Doshisha University offers English-based degree programs designed for degree-seeking graduate students.

    International science and technology course.

     

    Doshisha University offers a variety of scholarships to enable international students to concentrate on their studies free from financial concerns.

    Reduced tuition for international students.

    PhD studentships

    All doctoral students age 34 or younger at the time of admission can receive a tuition exemption. So, free from financial concerns.

    Doctoral-Program Young Researcher Scholarship

     

    There are also competitive programs for the most talented graduate students:

    JSPS offers doctoral fellowships to international students

    Monbu-kagaku-sho: MEXT scholarship program for overseas students

    A number of countries have bilateral funding schemes. We advise checking details from individual embassies.

    Post-doctoral positions

    If you want to do a post-doc in our lab, the JSPS fellowships are an easy way to do this.

    JSPS Postdoctoral Fellowship for Foreign Researchers (2 years)

     

    Conditions for JSPS Postdoctoral Fellowship for Foreign Researchers:

    1. hold non-Japanese nationality

    2. have an earned doctorate outside Japan within recent 5 years or under age of 35. (PhD candidates are also eligible if their doctorate is awarded prior to their starting date)

    3. excellence in research (judged mainly by publications, academic awards and recommendation letter)

     

    In all cases, we recommend that prospective post-docs first make contact with us.

    Senior Scientists

    We very much welcome more senior scientists wishing to undertake sabbaticals or visiting fellowships. Please contact us.

  • Contact Me!

    Any inquiry is welcome.

  • PUBLICATIONS

    [83] Acceleration of Hydrolytic DNA Cleavage by Dicopper(II) Complexes with p-Cresol-Derived Dinucleating Ligands at Slightly Acidic pH and the Mechanistic Insights

    Masahito Kodera, Yuki Kadoya, Kenta Aso, Katsuki Fukui, Akiko Nomura, Yutaka Hitomi, Hiroaki Kitagishi

    Bull. Chem. Soc. Jpn, 2019, 92, 739-747.

     

    [82] Green fabrication of nanoporous BiVO4 films on ITO substrates for photoelectrochemical water-oxidation
    Sayuri Okunaka, Yutaka Hitomi and Hiromasa Tokudome*

    RSC Advances, 2018, 8, 31575-31580.

     

    [81] Development of Artificial Bleomycin: Pentadentate Monocarboxylamide Ligand Having a Spermine Tail for DNA Binding
    Akiko Nomura, Masahito Kodera, and Yutaka Hitomi*

    Peptide Science 2017, 2018, 154-155.

     

    [80] Hydrogen peroxide-reducing factor released by PC12D cells increases cell tolerance against oxidative stress
    Asami Muraishi; Emi Haneta; Yoshiro Saito*; Yutaka Hitomi; Mamoru Sano; Noriko Noguchi*
    Biological and Pharmaceutical Bulletin, 2018, 41(5) 777-785.

     

    [79] Macrophage-Mediated Delivery of Light Activated Nitric Oxide Prodrugs with Spatial, Temporal and Concentration Control
    Michael A. Evans, Po-Ju Huang, Yuji Iwamoto, Kelly N. Ibsen, Emory M. Chan, Yutaka Hitomi, Peter C. Ford*, and Samir Mitragotri*
    Chemical Science, 2018, 9, 3729-3741.

     

    [78] Structurally Simple Cell-permeable Porphyrins: Efficient Cellular Uptake and Photo-toxicity of Porphyrins with Four Peripheral Primary-amine-terminated Oligo(ethylene oxide) Chains
    N. Ohashi, A. Nomura, M. Kodera, and Y. Hitomi*
    Chemistry Letters, 2017, 46 (12), 1754-1756.

     

    [77] Specific Enhancement of Catalytic Activity by a Dicopper Core: Selective Hydroxylation of Benzene to Phenol with Hydrogen Peroxide

    T. Tsuji, A. A. Zaoputra, Y. Hitomi, K. Mieda, T. Ogura, Y. Shiota, K. Yoshizawa, H. Sato, and M. Kodera*
    Angewandte Chemie International Edition, 2017, 56(27), 7779-7782.

     

    [76] DNA Cleavage through Reductive Dioxygen Activation by Iron-Bleomycin Mimics with Carboxamido Ligation: Correlation between DNA Cleavage Efficacy and Redox Potential
    A. Nomura, Y. Iwamoto, K. Arakawa, A. Kashida, M. Kodera, and Y. Hitomi*
    Chemistry Letters, 2017, 46(8), 1109-1111.

     

    [75] Cellular Application of Cell-membrane Permeable Fluorescent Zinc Probe Having a Cationic Peptide Tail
    A. Nomura, A. Kashida, M. Kodera, and Y. Hitomi*
    Peptide Science 2016, 2017, 173-174.

     

    [74] Formation and High Reactivity of the anti-Dioxo Form of High-Spin μ-Oxodioxodiiron(IV) as the Active Species That Cleaves Strong C−H Bonds
    M. Kodera,* S. Ishiga, T. Tsuji, K. Sakurai, Y. Hitomi, Y. Shiota, P. K. Sajith, K. Yoshizawa, K. Mieda, T. Ogura
    Chemistry - A European Journal, 2016, 22 (17), 5924-5936.

     

    [73] Preparation of Fine Particles of Scheelite-Monoclinic Phase BiVO4 via an Aqueous Chelating Method for Efficient Photocatalytic Oxygen Evolution under Visible-light Irradiation

    S. Okunaka, H. Tokudome*, Y. Hitomi, and R. Abe*
    Journal of Materials Chemistry A, 2016, 4, 3926-3932.

     

    [72] Effect of central metal ions on the cytotoxicity of metalloporphyrins having a cationic peptide tail
    A. Nomura, N. Ohashi, R. Miyachi, M. Kodera and Y. Hitomi*

    Peptide Science 2015, 2016, 261-264.

     

    [71] C-O Bond Formation by Arene C-H Activation via Biomimetic and Organocatalytic
    Oxidation
    Yutaka Hitomi and Kengo Arakawa
    in Catalytic Transformations via C-H Activation 2, Science of Synthesis
    Ed. by J.-Q. Yu, 2015, pp. 287-313. Georg Thieme Verlag KG, Stuttgart/New York

     

    [70] Uncaging a Catalytic Hydrogen Peroxide Generator through the Photo-Induced Release of Nitric Oxide from a {MnNO}6 Complex

    Yuji Iwamoto, Masahito Kodera, and Yutaka Hitomi*
    Chemical Communications, 2015, 51, 9539-9542.

     

    [69] Mononuclear Nonheme Iron(III) Complexes that Show Superoxide Dismutase-like Activity and Antioxidant Effects against Menadione-Mediated Oxidative Stress

    Yutaka Hitomi*, Yuji Iwamoto, Akihiro Kashida, and Masahito Kodera
    Chemical Communications, 2015, 51, 8702-8704.

     

    [68] Facile Preparation of Stable Aqueous Titania Sols for Fabrication of Highly Active TiO2 Photocatalyst Films

    Sayuri Okunaka, Hiromasa Tokudome*, Yutaka Hitomi, and Ryu Abe*
    Journal of Materials Chemistry A, 2015, 3, 1688-1695.

     

    [67] Gold Nanoparticles Coated with Manganese-Porphyrin that Effectively Shorten the Longitudinal Relaxation Time of Water Molecules Depending on the Particle Size
    Yutaka Hitomi,* Kazuki Aoki, Ryosuke Miyachi, Junya Ohyama, Masahito Kodera, Tsunehiro Tanaka, and Fuminori Sugihara
    Chemistry Letters, 2014, 12, 1901-1903.

     

    [66] Synthesis, Stability and Reactivity of the First Mononuclear Nonheme Oxoiron(IV) Species with Monoamido Ligation: A Putative Reactive Species Generated from Iron-Bleomycin
    Yutaka Hitomi*, Kengo Arakawa, and Masahito Kodera
    Chemical Communications, 2014, 50 (56), 7485-7487.

     

    [65] Development of Green-Emitting Iron Complex-Based Fluorescent Probes for Intracellular Hydrogen Peroxide Imaging
    Yutaka Hitomi*, Toshiyuki Takeyasu, and Masahito Kodera
    Bulletin of the Chemical Society of Japan, 2014, 87(7), 819-824.
     
    [64] Nucleophilic Ring-opening of meso-Substituted 5-Oxaporphyrin by Oxygen, Nitrogen, Sulfur, and Carbon Nucleophiles
    Kazuhisa Kakeya, Masakatsu Aozasa, Tadashi Mizutani,* Yutaka Hitomi and Masahito Kodera
    Journal of Organic Chemistry, 2014, 79 (6), 2591-2600.

     

    [63] Roles of carboxylate donors in O-O bond scission of peroxodiiron(III) to high-spin oxodiiron(IV) with a new carboxylate-containing dinucleating ligand

    Masahito Kodera, Tomokazu Tsuji, Tomohiro Yasunaga, Yuka Kawahara, Tomoya Hirano, Yutaka Hitomi,Takashi Nomura, Takashi Ogura, Yoshio Kobayashi, Pookkottu K. Sajith, Yoshihito Shiota and Kazunari Yoshizawa

    Chemical Science, 2014, 5, 2282-2292.
     

    [62] Water Proton Relaxivity, Superoxide Dismutase-like Activity, and Cytotoxicity of a Manganese(III) Porphyrin Having Four Poly(ethylene glycol) Tails.
    Hitomi, Y.*; Ekawa, T.; Kodera, M.
    Chemistry Letters, 2014, 43 (5), 732-734.

     

    [61] Electronic Tuning of Nitric Oxide Release from Manganese Nitrosyl Complexes by Visible Light Irradiation: Enhancement of Nitric Oxide Release Efficiency by Nitro-Substituted Quinoline Ligand.
    Hitomi, Y.*; Iwamoto, Y.; Kodera, M.
    Dalton Transactions, 2014, 43, 2161-2167.

     

    [60] Iron Complex-Based Fluorescent Probes for Intracellular Hydrogen Peroxide Detection.
    Hitomi, Y.*;Takeyasu, T.; Kodera, M.
    Chemical Communications (Cambridge, United Kingdom) 2013, 49, 9929-9931.

     

    [59] An Iron(III) Tetradentate Monoamido Complex as a Nonheme Iron-Based Peroxidase Mimetic.

    Hitomi, Y.*; Hiramatsu, K.; Arakawa, K.;Takeyasu, T.; Hata, M.; Kodera, M.
    Dalton Transactions 2013, 42 (36), 12878-12882.

     

    [58] Electronic Tuning of Iron-Oxo Mediated C-H Activation: Effect of Electron Donating Ligand on Selectivity.
    Hitomi, Y.*; Arakawa, K.; Kodera, M.
    Chemistry - A European Journal 2013, 19 (43), 14697-14701..

     

    [57] Synthesis and Characterization of Ratiometric Fluorescent Zinc Ion Probe Having Cationic Short Peptide Tail.
    Hitomi, Y.*; Takeyasu, T.; Matsuda, S.; Nomura, A.; Kashida, A.; Hayashi, M.; Kodera, M.
    Peptide Science 2012, 49th, 297-300.

     

    [56] Oxidative DNA Cleavage by Synthetic Mononuclear Nonheme Iron Complex Having Cationic Short Peptide Tail for DNA Binding.
    Hitomi, Y.*; Nomura, A.; Matsuda, S.; Kashida, A.; Kodera, M.
    Peptide Science 2012, 49th, 279-282.

     

    [55] A silver complex with an N,S,S-macrocyclic ligand bearing an anthracene pendant arm for optical ethylene monitoring.
    Hitomi, Y.*; Nagai, T.; Kodera, M.
    Chemical Communications (Cambridge, United Kingdom) 2012, 48 (84), 10392-10394.

     

    [54] Reversible O-O Bond Scission of Peroxodiiron (III) to High-Spin Oxodiiron(IV) in Dioxygen Activation of a Diiron Center with a Bis-tpa Dinucleating Ligand as a Soluble Methane Monooxygenase Model.
    Kodera, M.; Kawahara, Y.; Hitomi, Y.; Nomura, T.; Ogura, T.; Kobayashi, Y.
    Journal of the American Chemical Society 2012, 134 (32), 13236-13239.

     

    [53] Synthesis, Reactivity, and Spectroscopic Properties of meso-Triaryl-5-oxaporphyrins.
    Kakeya, K.; Nakagawa, A.; Mizutani, T.; Hitomi, Y.; Kodera, M.
    Journal of Organic Chemistry 2012, 77 (15), 6510-6519.

     

    [52] Formation mechanism of metal nanoparticles studied by XAFS spectroscopy and effective synthesis of small metal nanoparticles.
    Tanaka, T.; Ohyama, J.; Teramura, K.; Hitomi, Y.
    Catalysis Today 2012, 183 (1), 108-118.

     

    [51] An Iron(III)-Monoamidate Complex Catalyst for Selective Hydroxylation of Alkane C-H Bonds with Hydrogen Peroxide.
    Hitomi, Y.*; Arakawa, K.; Funabiki, T.; Kodera, M.
    Angewandte Chemie, International Edition 2012, 51 (14), 3448-3452, S3448/1-S3448/19.

     

    [50] Detection of Enzymatically Generated Hydrogen Peroxide by Metal-Based Fluorescent Probe.
    Hitomi, Y.*; Takeyasu, T.; Funabiki, T.; Kodera, M.
    Analytical Chemistry (Washington, DC, United States) 2011, 83 (24), 9213-9216.

     

    [49] π Back-Bonding of Iron(II) Complexes Supported by Tris(pyrid-2-ylmethyl)amine and Its Nitro-Substituted Derivatives.
    Furukawa, S.; Hitomi, Y.*; Shishido, T.; Teramura, K.; Tanaka, T.
    Journal of Physical Chemistry A 2011, 115 (46), 13589-13595.

     

    [48] Synthesis and characterization of zinc chelator conjugated with cationic peptide.
    Hitomi, Y.*; Kashida, A.; Nomura, A.; Hayashi, M.; Kodera, M.
    Peptide Science 2011, 48th, 319-322.

     

    [47] Efficient aerobic oxidation of hydrocarbons promoted by high-spin nonheme Fe(II) complexes without any reductant.
    Furukawa, S.; Hitomi, Y.*; Shishido, T.; Tanaka, T.
    Inorganica Chimica Acta 2011, 378 (1), 19-23.

     

    [46] An in situ quick XAFS spectroscopy study on the formation mechanism of small gold nanoparticles supported by porphyrin-cored tetradentate passivants.
    Ohyama, J.; Teramura, K.; Higuchi, Y.; Shishido, T.; Hitomi, Y.; Aoki, K.; Funabiki, T.; Kodera, M.; Kato, K.; Tanida, H.; Uruga, T.; Tanaka, T.
    Physical Chemistry Chemical Physics 2011, 13 (23), 11128-11135.

     

    [45] Multistate CASPT2 Study of Native Iron(III)-Dependent Catechol Dioxygenase and Its Functional Models: Electronic Structure and Ligand-to-Metal Charge-Transfer Excitation.
    Nakatani, N.; Hitomi, Y.; Sakaki, S.
    Journal of Physical Chemistry B 2011, 115 (16), 4781-4789.

     

    [44] In Situ Au L3 and L2 edge XANES spectral analysis during growth of thiol protected gold nanoparticles for the study on particle size dependent electronic properties.
    Ohyama, J.; Teramura, K.; Shishido, T.; Hitomi, Y.; Kato, K.; Tanida, H.; Uruga, T.; Tanaka, T.
    Chemical Physics Letters 2011, 507 (1-3), 105-110.

     

    [43] In Situ Observation of Nucleation and Growth Process of Gold Nanoparticles by Quick XAFS Spectroscopy.
    Ohyama, J.; Teramura, K.; Higuchi, Y.; Shishido, T.; Hitomi, Y.; Kato, K.; Tanida, H.; Uruga, T.; Tanaka, T.
    ChemPhysChem 2011, 12 (1), 127-131.

     

    [42] Synthesis and Catalytic Performance of Organic-Inorganic Hybrid Mesoporous Material Having Basic Nanospace.
    Shishido, T.; Kawaguchi, T.; Iwashige, T.; Teramura, K.; Hitomi, Y.; Tanaka, T.
    Catalysis Letters 2010, 140 (3-4), 121-126.

     

    [41] Tris(2-picolinyl)methane and its copper(I) complex.
    Kajita, Y.; Tachi, Y.; Hitomi, Y.; Nakagawa, T.; Kishima, Y.; Kodera, M.; Letko, C. S.; Rauchfuss, T. B.
    Inorganic Syntheses 2010, 35, 74-77.

     

    [40] Efficient capping of growing gold nanoparticles by porphyrin having two disulfide straps over one face.
    Hitomi, Y.*; Ohyama, J.; Higuchi, Y.; Aoki, K.; Shishido, T.; Funabiki, T.; Kodera, M.; Tanaka, T.
    Bulletin of the Chemical Society of Japan 2010, 83 (11), 1392-1396.

     

    [39] Fast guest exchange of a 1:1 zinc porphyrin-amine host-guest complex via a six-coordinated zinc porphyrin.
    Hitomi, Y.*; Ohyama, J.; Takegoshi, M.; Ando, A.; Funabiki, T.; Kodera, M.; Tanaka, T.
    Bulletin of the Chemical Society of Japan 2010, 83 (8), 950-952.

     

    [38] Mechanism of Photooxidation of Alcohol over Nb2O5.
    Shishido, T.; Miyatake, T.; Teramura, K.; Hitomi, Y.; Yamashita, H.; Tanaka, T.
    Journal of Physical Chemistry C 2009, 113 (43), 18713-18718.

     

    [37] Size Controlled Synthesis of Gold Nanoparticles by Porphyrin with Four Sulfur Atoms.
    Ohyama, J.; Hitomi, Y.; Higuchi, Y.; Tanaka, T.
    Topics in Catalysis 2009, 52 (6-7), 852-859.

     

    [36] Synthesis and Characterization of a Binuclear Iron(III) Complex Bridged by 1-Aminocyclopropane-1-carboxylic Acid. Ethylene Production in the Presence of Hydrogen Peroxide.
    Ghattas, W.; Serhan, Z.; El Bakkali-Taheri, N.; Reglier, M.; Kodera, M.; Hitomi, Y.; Simaan, A. J.
    Inorganic Chemistry 2009, 48 (9), 3910-3912.

     

    [35] One-phase synthesis of small gold nanoparticles coated by a horizontal porphyrin monolayer.
    Ohyama, J.; Hitomi, Y.; Higuchi, Y.; Shinagawa, M.; Mukai, H.; Kodera, M.; Teramura, K.; Shishido, T.; Tanaka, T.
    Chemical Communications (Cambridge, United Kingdom) 2008, (47), 6300-6302.

     

    [34] XAFS Study of Tungsten L1- and L3-Edges: Structural Analysis of WO3 Species Loaded on TiO2 as a Catalyst for Photo-oxidation of NH3.
    Yamazoe, S.; Hitomi, Y.; Shishido, T.; Tanaka, T.
    Journal of Physical Chemistry C 2008, 112 (17), 6869-6879.

     

    [33] Identification of a copper(I) intermediate in the conversion of 1-aminocyclopropane carboxylic acid (ACC) into ethylene by Cu(II)-ACC complexes and hydrogen peroxide.
    Ghattas, W.; Giorgi, M.; Mekmouche, Y.; Tanaka, T.; Rockenbauer, A.; Reglier, M.; Hitomi, Y.; Simaan, A. J.
    Inorganic Chemistry 2008, 47 (11), 4627-4638.

     

    [32] Alkane hydroxylation catalyzed by a series of mononuclear nonheme iron complexes containing 4-nitropyridine ligands.
    Hitomi, Y.; Furukawa, S.; Higuchi, M.; Shishido, T.; Tanaka, T.
    Journal of Molecular Catalysis A: Chemical 2008, 288 (1-2), 83-86.

     

    [31] Promotion effect of tungsten oxide on photo-assisted selective catalytic reduction of NO with NH3 over TiO2.
    Yamazoe, S.; Masutani, Y.; Teramura, K.; Hitomi, Y.; Shishido, T.; Tanaka, T.
    Applied Catalysis, B: Environmental 2008, 83 (1-2), 123-130.

     

    [30] Kinetic study of photo-oxidation of NH3 over TiO2.
    Yamazoe, S.; Hitomi, Y.; Shishido, T.; Tanaka, T.
    Applied Catalysis, B: Environmental 2008, 82 (1-2), 67-76.

     

    [29] Visible Light Absorbed NH2 Species Derived from NH3 Adsorbed on TiO2 for Photoassisted Selective Catalytic Reduction.
    Yamazoe, S.; Teramura, K.; Hitomi, Y.; Shishido, T.; Tanaka, T.
    Journal of Physical Chemistry C 2007, 111 (38), 14189-14197.

     

    [28] Mechanism of Photo-Oxidation of NH3 over TiO2: Fourier Transform Infrared Study of the Intermediate Species.
    Yamazoe, S.; Okumura, T.; Hitomi, Y.; Shishido, T.; Tanaka, T.
    Journal of Physical Chemistry C 2007, 111 (29), 11077-11085.

     

    [27] Adsorption of manganese porphyrin on metal oxides and its enhanced catalytic activity on epoxidation reaction.
    Hitomi, Y.; Mukai, H.; Ohyama, J.; Shinagawa, M.; Shishido, T.; Tanaka, T.
    Chemistry Letters 2007, 36 (5), 660-661.

     

    [26] Liquid phase photooxidation of alcohol over niobium oxide without solvents.
    Ohuchi, T.; Miyatake, T.; Hitomi, Y.; Tanaka, T.
    Catalysis Today 2007, 120 (2), 233-239.

     

    [25] Mechanistic study on regioselective oxygenation reaction of 1,2-quinones with peroxybenzoic acids: Relevant to mechanisms of catechol dioxygenases.
    Hitomi, Y.; Yoshida, H.; Tanaka, T.; Funabiki, T.
    Journal of Molecular Catalysis A: Chemical 2006, 251 (1-2), 239-245.

     

    [24] Non-covalent modification of the heme-pocket of apomyoglobin by a 1,10-phenanthroline derivative.
    Hitomi, Y.; Mukai, H.; Yoshimura, H.; Tanaka, T.; Funabiki, T.
    Bioorganic & Medicinal Chemistry Letters 2006, 16 (2), 248-251.

     

    [23] Correlation of Spin States and Spin Delocalization with the Dioxygen Reactivity of Catecholatoiron(III) Complexes.
    Higuchi, M.; Hitomi, Y.; Minami, H.; Tanaka, T.; Funabiki, T.
    Inorganic Chemistry 2005, 44 (24), 8810-8821.

     

    [22] Catalytic oxygenative degradation of 4-chlorocatechol by a nonheme iron(III) complex-Mechanism and prevention of catechol ester formation.
    Hitomi, Y.; Higuchi, M.; Tanaka, T.; Funabiki, T.
    Journal of Molecular Catalysis A: Chemical 2005, 240 (1-2), 207-213.

     

    [21] Electron spray ionization mass study on dioxygenation process in the reaction of catecholato iron(III) complexes with molecular oxygen.
    Hitomi, Y.; Higuchi, M.; Tanaka, T.; Funabiki, T.
    Inorganica Chimica Acta 2005, 358 (12), 3465-3470.

     

    [20] Aerobic Catechol Oxidation Catalyzed by a Bis(μ-oxo)dimanganese(III,III) Complex via a Manganese(II)-Semiquinonate Complex.
    Hitomi, Y.; Ando, A.; Matsui, H.; Ito, T.; Tanaka, T.; Ogo, S.; Funabiki, T.
    Inorganic Chemistry 2005, 44 (10), 3473-3478.

     

    [19] Tuning of spin crossover equilibrium in catecholatoiron(III) complexes by supporting ligands.
    Hitomi, Y.; Higuchi, M.; Minami, H.; Tanaka, T.; Funabiki, T.
    Chemical Communications (Cambridge, United Kingdom) 2005, (13), 1758-1760.

     

    [18] A linear correlation between energy of LMCT band and oxygenation reaction rate of a series of catecholatoiron(III) complexes: initial oxygen binding during intradiol catechol oxygenation.
    Hitomi, Y.; Yoshida, M.; Higuchi, M.; Minami, H.; Tanaka, T.; Funabiki, T.
    Journal of Inorganic Biochemistry 2005, 99 (3), 755-763.

     

    [17] Chemical properties of sperm whale myoglobins reconstituted with monopropionate hemins.
    Hayashi, T.; Nakagawa, T.; Harada, K.; Matsuo, T.; Hitomi, Y.; Hisaeda, Y.
    Chemistry Letters 2004, 33 (11), 1512-1513.

     

    [16] Enhancement of enzymatic activity for myoglobins by modification of heme-propionate side chains.
    Hayashi, T.; Sato, H.; Matsuo, T.; Matsuda, T.; Hitomi, Y.; Hisaeda, Y.
    Journal of Porphyrins and Phthalocyanines 2004, 8 (1, 2 & 3), 255-264.

     

    [15] A reaction intermediate involved in oxygenation of catecholatoiron(III) complexes with molecular oxygen - relevance to catechol dioxygenases.
    Hitomi, Y.; Tase, Y.; Higuchi, M.; Tanaka, T.; Funabiki, T.
    Chemistry Letters 2004, 33 (3), 316-317.

     

    [14] On the mechanisms of oxygenations of catechols by oxygenases and their model complexes.
    Funabiki, T.; Yoshida, M.; Yoshida, H.; Tase, Y.; Ando, A.; Hitomi, Y.
    Journal of Inorganic Biochemistry 2003, 96, 135.

     

    [13] Contribution of heme-propionate side chains to structure and function of myoglobin: chemical approach by artificially created prosthetic groups.
    Hayashi, T.; Matsuo, T.; Hitomi, Y.; Okawa, K.; Suzuki, A.; Shiro, Y.; Iizuka, T.; Hisaeda, Y.; Ogoshi, H.
    Journal of Inorganic Biochemistry 2002, 91 (1), 94-100.

     

    [12] Oxygenative cleavage of catechols including protocatechuic acid with molecular oxygen in water catalyzed by water-soluble non-heme iron(III) complexes in relevance to catechol dioxygenases.
    Funabiki, T.; Sugio, D.; Inui, N.; Maeda, M.; Hitomi, Y.
    Chemical Communications (Cambridge, United Kingdom) 2002, (5), 412-413.

     

    [11] Structures and electronic properties of the catecholatoiron complexes in relation to catechol dioxygenases: chlorocatecholatoiron complexes are compared to the 3,5-di-tert-butylcatecholatoiron complex in the solid state and in solution.
    Funabiki, T.; Fukui, A.; Hitomi, Y.; Higuchi, M.; Yamamoto, T.; Tanaka, T.; Tani, F.; Naruta, Y.
    Journal of Inorganic Biochemistry 2002, 91 (1), 151-158.

     

    [10] Zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR.
    Hitomi, Y.; Outten, C. E.; O'Halloran, T. V.
    Journal of Inorganic Biochemistry 2001, 86, 265.

     

    [9] Extreme Zinc-Binding Thermodynamics of the Metal Sensor/Regulator Protein, ZntR.
    Hitomi, Y.; Outten, C. E.; O'Halloran, T. V.
    Journal of the American Chemical Society 2001, 123 (35), 8614-8615.

     

    [8] Interprotein electron transfer reaction regulated by an artificial interface.
    Hitomi, Y.; Hayashi, T.; Wada, K.; Mizutani, T.; Hisaeda, Y.; Ogoshi, H.
    Angewandte Chemie, International Edition 2001, 40 (6), 1098-1101.

     

    [7] Peroxidase activity of myoglobin is enhanced by chemical mutation of heme-propionates.
    Hayashi, T.; Hitomi, Y.; Ando, T.; Mizutani, T.; Hisaeda, Y.; Kitagawa, S.; Ogoshi, H.
    Journal of the American Chemical Society 1999, 121 (34), 7747-7750.

     

    [6] Enhancement of Peroxidase Activity by Use of Reconstituted Myoglobin
    Hayashi, T.; Takimura, T.; Aoyama, Y.; Hitomi, Y.; Suzuki, A.; Ogoshi, H.
    Journal of Inorganic Biochemistry 1999, 74, 156.

     

    [5] Structure and reactivity of reconstituted myoglobins: interaction between protein and polar side chain of chemically modified hemin.
    Hayashi, T.; Takimura, T.; Aoyama, Y.; Hitomi, Y.; Suzuki, A.; Ogoshi, H.
    Inorganica Chimica Acta 1998, 275-276 (1,2), 159-167.

     

    [4] Artificial Protein-Protein Complexation between a Reconstituted Myoglobin and Cytochrome c
    Hayashi, T.; Hitomi, Y.; Ogoshi, H.
    Journal of the American Chemical Society 1998, 120 (20), 4910-4915.

     

    [3] Photoinduced electron transfer from zinc porphyrin to a linked quinone in myoglobin.
    Hayashi, T.; Takimura, T.; Ohara, T.; Hitomi, Y.; Ogoshi, H.
    Journal of the Chemical Society, Chemical Communications 1995, (24), 2503-4.

     

    [2] Molecular recognition of horse heart apomyoglobin to monopropionate hemin: thermodynamic determination of two orientational isomers by 1H NMR spectra.
    Hayashi, T.; Hitomi, Y.; Suzuki, A.; Takimura, T.; Ogoshi, H.
    Chemistry Letters 1995, (10), 911-12.

     

    [1] Relationship between electron transfer and the structure of a quinone-linked zinc porphyrin with a flexible peptide spacer.
    Hayashi, T.; Takimura, T.; Hitomi, Y.; Ohara, T.; Ogoshi, H.
    Journal of the Chemical Society, Chemical Communications 1995, (5), 545-6.